ESA-SRB 2014* Sponsored by:
In an attempt to better manage overweight and obesity to help prevent diabetes and other diseases, there is much focus on reducing body weight, body fat and the risk of metabolic disease, with little attention to possible long-term adverse effects of weight loss interventions. However, with the expansion of obesity in all age groups in Australia and other countries, as well as increasing life expectancy, it is important to consider potential long-term effects of diet-induced weight loss and energy restriction. Of particular concern are the potential adverse effects of these obesity interventions on neuroendocrine status and body composition.
Energy deficit in lean or obese animals or humans stimulates appetite and reduces energy expenditure, thereby contributing to weight regain. Often overlooked in obesity interventions, however, is the effect of energy restriction on neuroendocrine status, and the impact this could have on body composition and strength.
This breakfast session covers hypothalamic pathways that could influence bone mass and muscle strength during diet-induced weight loss in overweight or obese humans and animals, notably via effects on circulating concentrations of hormones such as peptide YY or cortisol. It also highlights gaps in current knowledge and ideas for future research efforts.
As our population becomes increasingly obese, from a younger age, with more people using weight management strategies for longer, this line of enquiry could guard against inadvertent increases in frailty, fractures and loss of independence in our ageing population.
Topics covered:
- Effects of energy restriction on neuroendocrine status in overweight or obese animals and humans.
- Effects of diet-induced weight loss on bone mass or muscle strength in overweight or obese adults.
- Mechanisms by which neuropeptides or hormones that regulate appetite and glucose homeostasis regulate bone mass in mice.
Speakers:
Assoc Prof Amanda Salis and team (Ms Jessica Zibellini, Ms Amy D Nguyen)