A/Prof Mitchell Lawrence leads the Genitourinary Oncology Laboratory in the Department of Anatomy and Developmental Biology and Biomedicine Discovery Institute, Monash University. He also has appointments at the Peter MacCallum Cancer Centre and Cabrini Health. His research on prostate and penile cancer focusses on tumour pathology, and novel therapies. With the Melbourne Urological Research Alliance (MURAL), A/Prof Lawrence uses patient-derived models to uncover why some patients’ tumours are more aggressive than others and to identify how to treat these tumours more effectively. This is leading to changes in international clinical practice, concurrent clinical trials, and partnerships with industry.